Gordan Lauc, PhD

Professor of Biochemistry and Molecular Biology

A. Kovacica 1, 10000 Zagreb, Croatia
Phone: +385 1 639 4467
Fax: +385 1 639 4400
E-mail: glauc@pharma.hr

Research Interest

Nearly all proteins are glycosylated and their glycan parts have numerous structural, functional, and regulatory roles. However, due to structural complexity of glycans and the absence of a direct genetic template, the knowledge about glycans is lagging significantly behind the knowledge about DNA and proteins. Dr. Lauc has been publishing in the field of glycobiology for over 20 years and his current interest is focused on the complex genetics of protein glycosylation and the role of alternative glycosylation in physiological and pathophysiological processes. His laboratory performed the first population study of the human plasma glycome (Knezevic et al, J. proteome Res, 2009), which revealed significant variability in glycome composition between individuals. At the same time, composition of the glycome within an individual was found to be remarkably stable (Gornik et al, Glycobiology, 2009). The introduction of high-throughput studies of the glycome enabled glycomics to meet modern genomics and Dr. Lauc led the first genome wide association study of the human plasma glycome (Lauc et al, PLoS Genetics, 2010).

Total plasma glycome is a mixture of glycans released from different proteins, thus protein-specific elements of glycosylation are lost in glycomics studies. Analysis of individual glycoproteins is needed to resolve this issue and, after developing adequate technology, the laboratory of Dr. Lauc performed the first large scale study of the glycome of an individual protein, in this case human IgG. This study revealed that on the level of an individual protein, variability of glycosylation is even larger than for the total plasma glycome (Pucic et al, Mol Cell Protemics, 2011). Genome wide association studies of the IgG glycome, and a number of diagnostic and prognostic biomarker studies (diabetes, colorectal cancer, ulcerative colitis, etc) are currently in progress.



Dr. Gordan Lauc is Professor of Biochemistry and Molecular Biology at the University of Zagreb Faculty of Pharmacy and Biochemistry and Board Member of Genos Ltd, a private research organization in Croatia. He was born in Osijek in 1970, graduated molecular biology at the University of Zagreb Faculty of Science in 1992, and obtained PhD in Biochemistry and the University of Zagreb in 1995. He got his postdoctoral training at the Institute for Medical Physics and Biophysics in Münster and Johns Hopkins University in Baltimore. Since 1993 he is employed at the Faculty of Pharmacy and Biochemistry in Zagreb. Between 1998 and 2010 he was also part-time employed at the University of Osijek School of Medicine where he founded DNA laboratory for the identification of war victims and also served as Vice-Dean for Science between 2001 and 2005. Dr. Lauc is author of over 100 research papers published in international journals and six international patents. His laboratory performed the first large scale studies of the human plasma glycome (in 2009) and human IgG glycome (in 2011), which were the basis for the subsequent first GWAS of the human glycome. He was invited to lecture at numerous international conferences, elected for visiting professor at the Johns Hopkins University and in 2011 also inducted in the prestigious Johns Hopkins Society of Scholars. He chaired and co-chaired a number of conferences, including the “European Science Foundation Exploratory Workshop on Glycoscience” which resulted in the creation of the “European Glycoscience Forum”. Professor Lauc was a chairman of the committee that prepared Croatian National Action plan for the increased investment in research in development (2007), and is currently a member of the National Science Council and President of the National Council for Natural Sciences. He is a member of the Board of the International Glycoscience Organization and the Steering Committee of the European Glycoscience Forum.